In the context of lung protective ventilation, positive end-expiratory pressure (PEEP) is applied to open collapsed lung regions and keep the lung open. Registered on 9 September 2019-retrospectively registered. A low O/R ratio induced by high PEEP might indicate a more homogeneous ventilation and improvement of VQMatch. ConclusionsĬhange of ventilation–perfusion matching was associated with regional overdistention and recruitment induced by PEEP. ΔVQMatch % (VQMatch % at high PEEP minus that at ZEEP) was significantly correlated with recruited pixels ( r = 0.468, P = 0.009), overdistended pixels ( r = − 0.666, P 20% in response to high PEEP. Increasing PEEP resulted in recruitment mainly in dorsal regions and overdistension mainly in ventral regions. DeadSpace %, Shunt %, and VQMatch % were calculated based on lung EIT perfusion and ventilation images. The number of overdistended pixels over the number of recruited pixels (O/R ratio) was calculated, and the patients were divided into low O/R (O/R ratio 8 s). EIT measurements were performed at zero end-expiratory pressures (ZEEP) and subsequently at high (12–15 cmH 2O) PEEP. The study was conducted prospectively on 30 adult mechanically ventilated patients: 18/30 with ARDS and 12/30 with high risk for ARDS. ![]() This study aimed to investigate the association between PEEP-induced lung overdistension/recruitment and VQMatch by electrical impedance tomography (EIT). ![]() High positive end-expiratory pressures (PEEP) may induce overdistension/recruitment and affect ventilation–perfusion matching (VQMatch) in mechanically ventilated patients.
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